Tuesday, December 05, 2006

Miscarriages can be Prevented

Treatment of Antinuclear Antibodies
Women with ANA are treated with prednisone, a corticosteroid, which suppresses the inflammatory process and stabilizes the cell. Prednisone does not pass through the placenta easily and is also broken down by enzymes in the placenta so that the fetus is exposed to only trace amounts. Additionally, the body produces the equivalent of 8 mg per day of this corticosteroid. When indicated, Prednisone should be started prior to conception.

Treatment for Antiphospholipid Antibodies
Antiphospholipid antibodies are treated with low dose (baby) aspirin and a blood thinner called Heparin. Heparin is a very large molecule and is unable to cross the placenta. Aspirin is able to cross the placenta but the dose used is so small that the fetus is unaffected. The effectiveness of treatment is much greater when the medication, if indicated, is started prior to conception and continued throughout the pregnancy. All medication, if indicated should be discussed with one's physician.

Treatment for Antithyroid Antibodies
In IVF patients, antithyroid antibodies (ATAs) are treated with intravenous immune globulin (IVIg) before the IVF transfer. There is no specific treatment for ATA in patients with recurrent miscarriage unless it is associated with other abnormalities.

Treatment for Immunophenotypes
Women who have an elevation of NK cells are candidates for immunologlobulin G infusion (IVIg). The dosage of IVIg is 400 mg/kg/day for three consecutive days, monthly, until the NK cells become normal or until the 28th week of pregnancy. In some studies, autoantibodies to phospholipid and nuclear epitopes were demonstrably lower after IVIg. Some researchers have used Enbrel, a TNF alpha inhibitor, instead of, or in addition to IVIg. Presently, there is not enough data to assess the true efficacy of Enbrel therapy.

Full article: http://www.americanfertility.com/pdfs/miscarriages.pdf

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