UroToday.com - Dewan and colleagues conducted a study which demonstrated that the prevalence of y-chromosome microdeletions was higher in patients (couples) undergoing evaluation for recurrent pregnancy loss (n=17) compared to 18 fertile couples without pregnancy loss and 10 infertile men.
Eighty-two (82%) percent of the men from the couples with recurrent pregnancy loss as compared to 0% in the normally fertile males and 20% in the infertile males were found to have microdeletions in the AZFc region of the Y chromosome.
These findings do not only provide an explanation for recurrent miscarriage in a select population, but may have implications for couples utilizing testicular sperm acquisition and IVF/ICSI. This finding supports the "complete" genetic evaluation for patients entertaining the utilization of these technologies.
Full article: http://www.medicalnewstoday.com/medicalnews.php?newsid=58697
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