Human Reproduction 2005 20(8):2325-2329; doi:10.1093/humrep/deh888
BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities.
METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3–11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively.
RESULTS: The mean±SD values for bisphenol A in patients were 2.59±5.23ng/ml, significantly higher than the 0.77±0.38ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage.
CONCLUSION: Exposure to bisphenol A is associated with recurrent miscarriage.
Full Article: http://humrep.oxfordjournals.org/cgi/content/full/20/8/2325?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Feb.+28+issue&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
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