All of this means that genes matter, and they matter in ways we can possibly predict. For example, imagine a population where everyone has blood group O (many Native American tribes are like this) and another where everyone has blood A (I believe this is close to true for the Blackfeet). If you make the claim (which is empirically defensible, see links above) that women who are O blood group will have much higher rates of miscarriage when they are carrying babies from males who are of blood group A, you can conclude that matings between the first population and second will have reduced fertility.
But, the same applies to people from populations where there is a fair amount of blood group variation. If a woman from a village in Norway of blood group O marries a man from the same village of blood group A, even if they are cousins she will have the same heightened risk of miscarriage. There's nothing mystical in the blood here, it's simple genetics. The likelihood is a product of clear and distinct factors.
Full story: http://scienceblogs.com/gnxp/2008/10/the_prenatal_wages_of_interrac.php
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