Monday, January 08, 2007

Y-Chromosome Microdeletions And Recurrent Pregnancy Loss - Dewan and colleagues conducted a study which demonstrated that the prevalence of y-chromosome microdeletions was higher in patients (couples) undergoing evaluation for recurrent pregnancy loss (n=17) compared to 18 fertile couples without pregnancy loss and 10 infertile men.

Eighty-two (82%) percent of the men from the couples with recurrent pregnancy loss as compared to 0% in the normally fertile males and 20% in the infertile males were found to have microdeletions in the AZFc region of the Y chromosome.

These findings do not only provide an explanation for recurrent miscarriage in a select population, but may have implications for couples utilizing testicular sperm acquisition and IVF/ICSI. This finding supports the "complete" genetic evaluation for patients entertaining the utilization of these technologies.

Full article:

No comments: